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Comprehensive Analysis of Parasite Biology - From Metabolism to Drug Discovery

Condition: BRAND NEW
ISBN: 9783527339044
Author(s): Müller
Format: Hardcover
Year: 2016
Publisher: Wiley-VCH
Dimensions: 1700 x 1700 x 2440 (w x l x h)
Pages: 576
Series: Drug Discovery in Infectious Diseases

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Description:
Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art 'omics' technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

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