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Methods in Enzymology Autophagy in Mammalian Systems

1st Edition

Part B

Autophagy in Mammalian Systems,
1st Edition,
Daniel Klionsky,
ISBN9780123745477
Methods in Enzymology
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Editor : D Klionsky
Imprint: Academic Press
Print Book ISBN : 9780123745477
Pages: 560
Dimensions: 229 X 152
RRP: $282.00

Description

This is the companion volume to Daniel Klionsky’s Autophagy: Lower Eukaryotes, which features the basic methods in autophagy covering yeasts and alternative fungi (aspergillus, podospora, magnaporthe). Klionsky is one of the leading authorities in the field. He is the editor-in-chief of Autophagy. The November 2007 issue of Nature Reviews highlighted his article, “Autophagy: From phenomenology to molecular understanding in less than a decade.” He is currently editing guidelines for the field, with 230 contributing authors, that will publish in Autophagy.

Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal “house cleaning” in the cell is called autophagy - literally self-eating. Breakthroughs in understanding the molecular basis of autophagy came after the cloning of ATG1 (autophagy-related gene 1) in yeast. (To date, 30 additional yeast genes have been identified.) These ATG genes in yeast were the stepping stones to the explosion of research into the molecular analysis of autophagy in higher eukaryotes. In the future, this research will help to design clinical approaches that can turn on autophagy and halt tumor growth.

Readership

Researchers in biochemistry, cell and molecular biology, oncology, pharmacology
his volume, along with "Autophagy: Lower Eukaryotes", marks the seminal collection of methods in the burgeoning field of autophagy (an internal “house-cleaning” mechanism in cells).
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