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Modeling Dose-response Microarray Data in Early Drug Development Experiments Using R

Condition: BRAND NEW
ISBN: 9783642240065
Author(s):
Format: Paperback
Year: 2012
Edition: 2012th
Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Dimensions: 155 x 15 x 235 (w x l x h)
Pages: 297
Series: Use R!

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Description:
This book focuses on the analysis of dose-response microarray data in pharmaceutical settings, the goal being to cover this important topic for early drug development experiments and to provide user-friendly R packages that can be used to analyze this data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as inference under order restrictions and non-linear parametric models, which are used in the second part of the book. Part II is the core of the book, in which we focus on the analysis of dose-response microarray data.
Methodological topics discussed include: * Multiplicity adjustment * Test statistics and procedures for the analysis of dose-response microarray data * Resampling-based inference and use of the SAM method for small-variance genes in the data * Identification and classification of dose-response curve shapes * Clustering of order-restricted (but not necessarily monotone) dose-response profiles * Gene set analysis to facilitate the interpretation of micr Please click here to ask a question
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