Snakes on a Plane (2006)

When Sean Jones witnesses a murder, he is asked to fly from Hawaii to Los Angeles to testify against the notorious gangster Eddie Kim. However, Kim has paid an assassin to release a crate-full of deadly snakes loose when the plane is 30,000 feet in the air. Only FBI agent Neville Flynn can protect Sean and rally the passengers together in hope of landing in L.A. alive...