Ham (Samberg), the grandson of the first chimp in outer space, has been happily eking out a living as a chimp cannonball in a third-rate circus when the space agency makes him an offer he can't refuse. A wormhole has transported the Infinity Space Probe into the farthest reaches of the universe. As a political PR stunt, Ham is recruited to join a team of specially trained ape astronauts assigned to rescue the lost vessel. His love of flashy acrobatics and aerial manoeuvres make Ham a successful high-flyer, but his irreverent antics and goofball humour quickly alienate his professional astro-chimp colleagues. Ham spends most of his time tweaking the ship's pompous commander, Titan (Warburton), or flirting with Luna (Hines), his fetching lieutenant, but as the only one immune to the effects of the wormhole, he is indispensable to the mission.

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