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With Spain now united- Ferdinand looked to his daughters to further his ambitions. All too often- Isabella found herself torn between his brilliant plans and her love for her children. During the last years of Isabellas reign it seemed there was a curse on the royal house which struck at the children of the sovereigns. Tragedy followed tragedy - the Infanta Isabella- a broken-hearted widow; Juana- driven to madness by her husbands philandering; and the sorrow of parting with young Catalina- destined to become Katharine of Aragon- wife to Henry VIII and Queen of England ......